PPARガンマを活性させる82の方法

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PPARγを活性化させる

関連記事

PPARとアルツハイマー病

PPARガンマを活性する30の方法

PPARγ活性 栄養化合物

EPA・DHA

PPARγのアップレギュレーション

Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease - PubMed
Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease
リノレン酸

セージ抽出のリノレン酸。12-O-メチルカルノシン酸、α-リノレン酸によるPPARγの活性

Activation of the nuclear receptor PPARγ by metabolites isolated from sage (Salvia officinalis L.) - PubMed
Selected metabolites from Salvia officinalis were able to activate PPARγ and hence, the anti-diabetic activity of this plant could in part be mediated through t
リノール酸

PPARα、γの活性化

Fatty acids and immune responses--a new perspective in searching for clues to mechanism - PubMed
Dietary essential fatty acids are the precursors for eicosanoids. Among the eicosanoids derived from arachidonic acid, prostaglandin (PG) E2 is known to possess

MCTオイル 

オメガ6脂肪酸

オメガ3脂肪酸

ビタミンA
All-trans-retinoic acid represses obesity and insulin resistance by activating both peroxisome proliferation-activated receptor beta/delta and retinoic acid receptor - PubMed
Many biological activities of all-trans-retinoic acid (RA) are mediated by the ligand-activated transcription factors termed retinoic acid receptors (RARs), but
ビタミンD
All-trans-retinoic acid represses obesity and insulin resistance by activating both peroxisome proliferation-activated receptor beta/delta and retinoic acid receptor - PubMed
Many biological activities of all-trans-retinoic acid (RA) are mediated by the ligand-activated transcription factors termed retinoic acid receptors (RARs), but
ビタミンE

トコトリエノール

Vitamin E tocotrienols improve insulin sensitivity through activating peroxisome proliferator-activated receptors - PubMed
Vitamin E is comprised of two classes of compounds: tocopherols and tocotrienols. Tocotrienol-enriched palm oil has been shown to help reduce blood glucose leve

αトコフェロール

Alpha-tocopherol modulates human umbilical vein endothelial cell expression of Cu/Zn superoxide dismutase and catalase and lipid peroxidation - PubMed
Recent studies suggest the potential of alpha-tocopherol as a gene regulator, possibly through peroxisome proliferator-activated receptor gamma (PPARgamma) acti

γトコフェロール

Gamma (gamma) tocopherol upregulates peroxisome proliferator activated receptor (PPAR) gamma (gamma) expression in SW 480 human colon cancer cell lines - PubMed
Our data suggest that both alpha and gamma tocopherol can upregulate the expression of PPARgamma which is considered an important molecular target for colon can

アルファリポ酸

グリシン

セレニウム

亜鉛
Peroxisome proliferator activated receptors alpha and gamma require zinc for their anti-inflammatory properties in porcine vascular endothelial cells - PubMed
Zinc is an essential structural component of various proteins and is crucial for the integrity of the vascular endothelium. The present study focused on the eff
Synthesis and anticancer properties of water-soluble zinc ionophores - PubMed
Several water-solubilized versions of the zinc ionophore 1-hydroxypyridine-2-thione (ZnHPT), synthesized as part of the present study, have been found both to i
リチウム
Effects of lithium and valproic acid on gene expression and phenotypic markers in an NT2 neurosphere model of neural development - PubMed
Mood stabilising drugs such as lithium (LiCl) and valproic acid (VPA) are the first line agents for treating conditions such as Bipolar disorder and Epilepsy. H
フラクトオリゴ糖・マンノオリゴ糖

RXR

PPARはRXRとヘテロダイマーの形をとることにより活性化される。

そのためPPARγを活性させるには、RXRも活性化させる必要がある。

ビタミンA
Vitamin A prevents high fat diet-induced ACF development and modifies the pattern of expression of peroxisome proliferator and retinoic acid receptor m-RNA - PubMed
Some dietary compounds, among them fats, are modulators of colon cancer risk. This study reports the modulating effects of n-6, with or without vitamin A, on pr
βカロテン
beta-Carotene induces apoptosis and up-regulates peroxisome proliferator-activated receptor gamma expression and reactive oxygen species production in MCF-7 cancer cells - PubMed
Although the pharmacological role of beta-carotene in the prevention and treatment of many cancer cells has received increasing attention, the molecular mechani

PPARガンマ活性 ハーブ類

緑茶カテキン
(-)-Catechin promotes adipocyte differentiation in human bone marrow mesenchymal stem cells through PPAR gamma transactivation - PubMed
Green tea intake has been shown to confer various health benefits to patients suffering from metabolic disorders. Here, we studied the effect of several major g
アストラガルス
Differential effects of isoflavones, from Astragalus membranaceus and Pueraria thomsonii, on the activation of PPARalpha, PPARgamma, and adipocyte differentiation in vitro - PubMed
Compounds that target the peroxisome proliferator-activated receptors PPARalpha and PPARgamma are used to correct dyslipidemia and to restore glycemic balance,
クルクミン
Chemopreventive drug development: perspectives and progress - PubMed
Chemoprevention drug development has the goal of identifying safe and effective chemopreventive agents for clinical use. Several distinctive strategies are purs
ミルクシスル
beta-Carotene induces apoptosis and up-regulates peroxisome proliferator-activated receptor gamma expression and reactive oxygen species production in MCF-7 cancer cells - PubMed
Although the pharmacological role of beta-carotene in the prevention and treatment of many cancer cells has received increasing attention, the molecular mechani
バナナレクチン
ニンニクレクチン
メランジン(ミカン)Limnocitrus littoralis

Limnocitrus littoralis

Reverse pharmacognosy: identifying biological properties for plants by means of their molecule constituents: application to meranzin - PubMed
Reverse pharmacognosy aims at finding biological targets for natural compounds by virtual or real screening and identifying natural resources that contain the a
甘草
Phenolics from Glycyrrhiza glabra roots and their PPAR-gamma ligand-binding activity - PubMed
Bioassay-guided fractionation of the EtOH extract of licorice (Glycyrrhiza glabra roots), using a GAL-4-PPAR-gamma chimera assay method, resulted in the isolati
レスベラトロール
Peroxisome proliferator-activated receptor gamma as a molecular target of resveratrol-induced modulation of polyamine metabolism - PubMed
Previous results indicate that the polyphenol resveratrol inhibits cell growth of colon carcinoma cells via modulation of polyamine metabolic key enzymes. The a
イタチハギ(Amorfrutins)
Amorfrutins are potent antidiabetic dietary natural products - PubMed
Given worldwide increases in the incidence of obesity and type 2 diabetes, new strategies for preventing and treating metabolic diseases are needed. The nuclear
ネオリグナン/ごま、アカゴマ

PPARγアゴニスト

Prebiotics and lipid metabolism - PubMed
Prebiotics are defined as nondigestible food ingredients that beneficially affect the host by selectively stimulating the growth or the activity of one or a lim
トリゴネリン
ヒマワリヒヨドリ(Chromolaena odorata)
PPARγ agonist from Chromolaena odorata - PubMed
A phytochemical investigation of Chromolaena odorata resulted in the isolation of five new compounds, 5aα,6,9,9aβ,10-pentahydro-10β-hydroxy-7-methylanthradioxol
A peroxisome proliferator-activated receptor-gamma agonist and other constituents from Chromolaena odorata - PubMed
Peroxisome proliferator-activated receptors (PPARs) are key regulators of lipid and glucose metabolism and have become important therapeutic targets for various
ジャズダマ
香醋
カルノシン酸/セージ、ローズマリー
Carnosic acid and carnosol, phenolic diterpene compounds of the labiate herbs rosemary and sage, are activators of the human peroxisome proliferator-activated receptor gamma - PubMed
Peroxisome proliferator-activated receptor gamma (PPARgamma) is a ligand activated transcription factor, belonging to the metazoan family of nuclear hormone rec
エラグ酸/赤ワイン
Red wine: a source of potent ligands for peroxisome proliferator-activated receptor γ - PubMed
Moderate red wine consumption has been correlated with lower incidences of cardiovascular diseases, inflammation, and metabolic diseases such as type 2 diabetes
しょうが
シナモン
ルテオリン

PPARγパーシャルアゴニスト

Mode of peroxisome proliferator-activated receptor γ activation by luteolin - PubMed
The peroxisome proliferator-activated receptor γ (PPARγ) is a target for treatment of type II diabetes and other conditions. PPARγ full agonists, such as thiazo

http://www.naro.affrc.go.jp/project/results/laboratory/warc/2010/wenarc10-31.html

THC デルタ9 – テトラヒドロカンナビノール
Novel time-dependent vascular actions of Delta9-tetrahydrocannabinol mediated by peroxisome proliferator-activated receptor gamma - PubMed
Cannabinoids have widespread effects on the cardiovascular system, only some of which are mediated via G-protein-coupled cell surface receptors. The active ingr
グッグル

グッグルの木から抽出されたググリピッド(Commiphora mukul)のPPARγ活性による高糖尿病効果

Identification of a novel agonist of peroxisome proliferator-activated receptors alpha and gamma that may contribute to the anti-diabetic activity of guggulipid in Lep(ob)/Lep(ob) mice - PubMed
The ethyl acetate extract of the gum of the guggul tree, Commiphora mukul (guggulipid), is marketed for the treatment of dyslipidaemia and obesity. We have foun

スクリーニング

52のハーブ抽出物 トップ10

  • Alisma plantago aquatica (ze xie/european waterplantain)ウォータープランテーン
  • Catharanthus roseus (madagascar periwinkle) ニチニチソウ
  • Acorus calamus (sweet calamus) ショウブ
  • Euphorbia balsamifera (balsam spurge) ユーフォルビア・バルサミフェラ
  • Jatropha curcas (barbados nut) ナンヨウアブラギリ
  • Origanum majorana (marjoram) マジョラム
  • Zea mays (corn silk) とうもろこしの毛
  • Capsicum frutescens (chilli) キダチトウガラシ
  • Urtica dioica (stinging nettle) イラクサ
Screening of herbal extracts for activation of the human peroxisome proliferator-activated receptor - PubMed
The peroxisome proliferator-activated receptors play a pivotal role in metazoan lipid and glucose homeostasis. Synthetic activators of PPARalpha (fibrates) and

57000以上のハーブ バーチャルスクリーニング

  • オレアノン酸(Oleanonic acid) オレオレジン/Pistacia lentiscus var
  • キオス・マスティックガム(Chios mastic gum)
Pharmacophore-driven identification of PPARγ agonists from natural sources - PubMed
In a search for more effective and safe anti-diabetic compounds, we developed a pharmacophore model based on partial agonists of PPARγ. The model was used for t
PPARγ、PPARαの二重活性アゴニスト
  • ゲニステイン
  • ビオカニンA
  • サルガキノイン酸
  • サルガヒドロキノイン酸
  • レスベラトロール
  • アモルファスチルボール

α-エレオステアリン酸

81の天然化合物スクリーニング

Dietary α-eleostearic acid ameliorates experimental inflammatory bowel disease in mice by activating peroxisome proliferator-activated receptor-γ - PubMed
This study serves as the first significant step toward a large-scale VS protocol for natural PPARγ agonist screening that includes a massively diverse ligand li

200の天然化合物 バーチャルスクリーニング

psi-baptigenin

3′,4′-(メチレンジオキシ)-7-ヒドロキシイソフラボン

ヘスペリジン(hesperidin)
  • レッドクローバー(Trifolium pratense)
  • マンリョウ(Ardisia crenata Sims)
  • ブラジリアンチューリップウッド(Dalbergia frutescens)
  • 柑橘類

アピゲニン、クリシン、ビオカニン-A、ゲニステイン

Novel PPAR-gamma agonists identified from a natural product library: a virtual screening, induced-fit docking and biological assay study - PubMed
Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) plays an essential role in lipid and glucose homeostasis. It is recognized as the receptor of the

 

Structure-based pharmacophore screening for natural-product-derived PPARgamma agonists - PubMed
Structure-based pharmacophore screening for natural-product-derived PPARgamma agonists

PPARγ活性化 医薬

ピオグリタゾン

(直接PPARγを刺激するのではなくCdk5によるPPARγのリン酸化を阻害する)

アルツハイマー患者へのピオグリタゾン臨床第三相試験

https://www.takeda.co.jp/news/2013/20130827_5943.html

徐放製剤0.8mg/ 日 投与 2年間

 

無作為化オープンコントロール試験(2型糖尿病アルツハイマー病患者)

投与群では頭頂葉の血流と認知機能が改善したが対照郡では改善を示さなかった。

Efficacy of PPAR-γ agonist pioglitazone in mild Alzheimer disease - PubMed
To test the effects of the PPAR-γ agonist pioglitazone on cognition, regional cerebral blood flow (rCBF), and plasma levels of Aβ40 and Aβ42, we conducted a 6-m

 

ピオグリタゾンは脳内を透過するが、限定的である。

Disposition of the new antidiabetic agent pioglitazone in rats, dogs, and monkeys - PubMed
The disposition of pioglitazone (CAS 105355-27-9, AD-4833) was studied after oral administration to rats, dogs, and monkeys using 14C-labeled drug. After oral d

ロシグリタゾン

ランダム化比較試験、軽度から中等度のアルツハイマー病患者。

ApoE4非保有者がロシグリタゾンに応答して認知的と機能的改善を示したが、ApoE44対立遺伝子保有者は改善を示さず機能低下が観察された。

Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease - PubMed
Mild-to-moderate AD patients were randomized to placebo or rosiglitazone (RSG) 2, 4 or 8 mg. Primary end points at Week 24 were mean change from baseline in AD

ロシグリタゾンによるマウスの脳のミトコンドリア生合成増加

Rosiglitazone induces mitochondrial biogenesis in mouse brain - PubMed
Rosiglitazone was found to simulate mitochondrial biogenesis in mouse brain in an apolipoprotein (Apo) E isozyme-independent manner. Rosiglitazone induced both

テルミサルタン

PPARパーシャルアゴニストであるテルミサルタンは、マウスのアミロイドβ沈着の減少を示し、認知機能低下を予防した。

Telmisartan prevented cognitive decline partly due to PPAR-gamma activation - PubMed
Telmisartan is a unique angiotensin receptor blocker (ARB) and partial agonist of peroxisome proliferator-activated receptor (PPAR)-gamma. Here, we investigated

その他

ロサルタン
イルベサルタン

他のアンジオテンシンⅡ受容体拮抗薬に比べPPARγ作用は弱目

ベキサロテン
介護時々放射能 ミクログリアとアルツハイマー病の新たな知見?

シルデナフィル

Sildenafil promotes adipogenesis through a PKG pathway - PubMed
Sildenafil is the first oral PDE5 inhibitor for the treatment of erectile dysfunction and pulmonary arterial hypertension. In the present study, we investigated

NSAID

インドメタシン
Nuclear receptor peroxisome proliferator-activated receptor-gamma is activated in rat microglial cells by the anti-inflammatory drug HCT1026, a derivative of flurbiprofen - PubMed
The peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is constitutively expressed in primary cultures of rat microglia, the main population of brain
イブプロフェン
Nuclear receptor peroxisome proliferator-activated receptor-gamma is activated in rat microglial cells by the anti-inflammatory drug HCT1026, a derivative of flurbiprofen - PubMed
The peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is constitutively expressed in primary cultures of rat microglia, the main population of brain

PPARγ活性化 ライフスタイル

運動
寒さ
空腹 断食
ケトンダイエット
日光浴
LLLT 660nm 30mw 5.4J
Low-level laser therapy restores the oxidative stress balance in acute lung injury induced by gut ischemia and reperfusion - PubMed
It remains unknown if the oxidative stress can be regulated by low-level laser therapy (LLLT) in lung inflammation induced by intestinal reperfusion (i-I/R). A

PPARγ阻害因子

オレウロペイン
Oleuropein as an inhibitor of peroxisome proliferator-activated receptor gamma
Oleuropein, the major phenolic compound found in olive leaves and oil, exerts antioxidant, anti-inflammatory and anti-atherogenic effects and suppresses the adi
Oleuropein enhances osteoblastogenesis and inhibits adipogenesis: the effect on differentiation in stem cells derived from bone marrow - PubMed
Our data suggest that oleuropein, highly abundant in olive tree products included in the traditional Mediterranean diet, could prevent age-related bone loss and
レスベラトロール
Modulation of peroxisome proliferator-activated receptor gamma stability and transcriptional activity in adipocytes by resveratrol - PubMed
The peroxisome proliferator-activated receptor (PPAR) gamma is essential for the formation and function of adipocytes. It is also involved in regulating insulin
銀ナノ粒子
Integrative analysis of genes and miRNA alterations in human embryonic stem cells-derived neural cells after exposure to silver nanoparticles - PubMed
Given the rapid growth of engineered and customer products made of silver nanoparticles (Ag NPs), understanding their biological and toxicological effects on hu
葉酸
Folate supplementation modifies CCAAT/enhancer-binding protein α methylation to mediate differentiation of preadipocytes in chickens - PubMed
Folate, an essential vitamin participating in 1-carbon metabolism leading to a methyl donor function, is a key factor inducing epigenetic changes. This study so
ケルセチン

PPAR3つのアイソフォームを活性化を阻害

Effects of the mango components mangiferin and quercetin and the putative mangiferin metabolite norathyriol on the transactivation of peroxisome proliferator-activated receptor isoforms - PubMed
Mangos are a source of bioactive compounds with potential health-promoting activity. This study evaluated the abilities of the mango components quercetin and ma

AMPK活性因子

AMPKはPPARγを阻害するため、AMPK活性因子はPPARγの阻害を促進する。

ベルベリン

AMPK活性(漢方の黄檗)癌細胞の増殖抑制作用がある。

メトホルミン

AMPK活性

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