抗酸化酵素 スーパーオキシドディスムターゼ(SOD)

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活性酸素関連記事

 

概要

https://ja.wikipedia.org/wiki/スーパーオキシドディスムターゼ

SODは、スーパーオキシドアニオン(O2)を酸素と過酸化水素(H2O2)へ変換する酸化還元酵素。

銅イオンと亜鉛イオン(Cu, ZnSOD)、マンガンイオン(MnSOD)、鉄イオン(FeSOD)などの金属イオンを持った酵素。

細胞質(Cu, ZnSOD) やミトコンドリア(MnSOD)に多く局在している。

寿命と相関するSOD活性

酸素消費量の多さに対してSOD活性の強さは、寿命と相関があると言われている。

SOD1は、細胞液中 SOD3は細胞外に存在する。

SOD-2(MnSOD)

ミトコンドリア内に存在し、ミトコンドリアで産生されたスーパーオキシド(ーO2)を毒性の低い過酸化水素と酸素に変換。

トレードオフ関係にあるSOD量

癌細胞を死滅させるにはスーパーオキシドが必要なため、SOD2が過剰にありすぎると、腫瘍転移の増大につながる。

一方でSODの過剰生産は活性酸素であるスーパーオキシドを抑制し、ハエの寿命を20%増加させるなど、SODの生産量はトレードオフの関係にある。

「superoxide dismutase mnsod」の画像検索結果

Absence of manganese superoxide dismutase delays p53-induced tumor formation
Manganese superoxide dismutase (MnSOD) is a mitochondrial antioxidant enzyme that is down-regulated in a majority of cancers. Due to this observation,…
アミロイドβへの影響

SOD2の過剰発現は、アミロイド班の沈着を減少させ、ADマウスの記憶障害を改善する。

Overexpression of SOD-2 Reduces Hippocampal Superoxide and Prevents Memory Deficits in a Mouse Model of Alzheimer's Disease - PubMed
Alzheimer's disease (AD) is a neurodegenerative disease characterized by impaired cognitive function and the deposition of extracellular amyloid plaques and int
Mitochondrial superoxide: a key player in Alzheimer's disease

MnSODノックアウトマウスでは、脳内のアミロイドβレベルおよびアミロイドβの負荷を有意に増加させる。

Increased Plaque Burden in Brains of APP Mutant MnSOD Heterozygous Knockout Mice - PubMed
A growing body of evidence suggests a relationship between oxidative stress and beta-amyloid (Abeta) peptide accumulation, a hallmark in the pathogenesis of Alz

SOD2の欠損は、アミロイド負荷を悪化させ、リン酸化タウレベルを増加させる。

Mitochondrial Oxidative Stress Causes Hyperphosphorylation of Tau - PubMed
Age-related neurodegenerative disease has been mechanistically linked with mitochondrial dysfunction via damage from reactive oxygen species produced within the

アルツハイマー病の治療標的としてのSOD-2活性

Reduction in Mitochondrial Superoxide Dismutase Modulates Alzheimer's Disease-Like Pathology and Accelerates the Onset of Behavioral Changes in Human Amyloid Precursor Protein Transgenic Mice - PubMed
Alzheimer's disease (AD) is associated with accumulations of amyloid-beta (Abeta) peptides, oxidative damage, mitochondrial dysfunction, neurodegeneration, and

パーキンソン病、レビー小体型認知症患者での高いMn-SOD発現

Human Brain Cortex: Mitochondrial Oxidative Damage and Adaptive Response in Parkinson Disease and in Dementia With Lewy Bodies - PubMed
Frontal cortex samples from frozen human brains were used to assess tissue respiration; content of mitochondria; mitochondrial oxygen uptake; activity of respir

MnSODの神経保護効果

Manganese Superoxide Dismutase Protects nNOS Neurons From NMDA and Nitric Oxide-Mediated Neurotoxicity - PubMed
Neuronal nitric oxide synthase (nNOS) neurons kill adjacent neurons through the action of NMDA-glutamate receptor activation, although they remain relatively re

 

SOD-2活性経路

PGC-1α

PPARγ

Sirt3

Activation of SIRT3 Attenuates Triptolide-Induced Toxicity Through Closing Mitochondrial Permeability Transition Pore in Cardiomyocytes - PubMed
Triptolide (TP), an active component of the traditional Chinese herb Tripterygium wilfordii Hook f. (TWHF), has multiple pharmacological effects. However, the s

Sirt1

N-acetyl-l-cysteine Ameliorates the PM 2.5-induced Oxidative Stress by Regulating SIRT-1 in Rats - PubMed
Silent information regulator 1 (SIRT1), a class III histone deacetylase, plays a major role in combating cellular oxidative stress injury. However, the role of

BDNF

Brain-derived Neurotrophic Factor Increases Expression of MnSOD in Human Circulating Angiogenic Cells - PubMed
Existing evidence suggests that brain-derived neurotrophic factor (BDNF) promotes survival and proliferation of endothelial cells, stimulates mobilization of he

Nrf2(熱ショック)

The Antioxidant Transcription Factor Nrf2 Contributes to the Protective Effect of Mild Thermotolerance (40°C) Against Heat Shock-Induced Apoptosis - PubMed
The exposure of cells to low doses of stress induces adaptive survival responses that protect cells against subsequent exposure to toxic stress. The ability of
SOD-2関連遺伝子SNPs

RS4880 G/G

SOD-2(MnSOD)活性剤

レスベラトロール

The Stilbenes Resveratrol, Pterostilbene and Piceid Affect Growth and Stress Resistance in Mammalian Cells via a Mechanism Requiring Estrogen Receptor Beta and the Induction of Mn-superoxide Dismutase - PubMed
The mitochondrial antioxidant enzyme, Mn superoxide dismutase (MnSOD), has been shown to confer cytoprotection and to regulate cell cycle progression. Resveratr

プテロスチルベン

ERK5/HDAC5-mediated, Resveratrol-, and Pterostilbene-Induced Expression of MnSOD in Human Endothelial Cells - PubMed
Resveratrol and pterostilbene can activate MnSOD expression through ERK5/HDAC5 pathway, thus alleviating mitochondrial oxidative stress in endothelial cells tha

カテキン MnSOD

Time-dependent Beneficial Effect of Chronic Polyphenol Treatment With Catechin on Endothelial Dysfunction in Aging Mice - PubMed
A controlled redox environment is essential for vascular cell maturation and function. During aging, an imbalance occurs, leading to endothelial dysfunction. We

豆、穀物 MnSOD

Grain and Bean Lysates Improve Function of Endothelial Progenitor Cells From Human Peripheral Blood: Involvement of the Endogenous Antioxidant Defenses - PubMed
Increased oxidative stress contributes to the functional impairment of endothelial progenitor cells (EPCs), the pivotal players in the servicing of the endothel
Barley Beta-Glucan Promotes MnSOD Expression and Enhances Angiogenesis Under Oxidative Microenvironment - PubMed
Manganese superoxide dismutase (MnSOD), a foremost antioxidant enzyme, plays a key role in angiogenesis. Barley-derived (1.3) β-d-glucan (β-d-glucan) is a natur

カスチンViticis Fructus MnSOD

Casticin Prevents DSS Induced Ulcerative Colitis in Mice Through Inhibitions of NF-κB Pathway and ROS Signaling - PubMed
Casticin, a compound purified from the Chinese herb Viticis Fructus, has been proven effective in preventing tumor progression in previous studies. Ulcerative c

ルテイン SOD-2

Lutein Extends the Lifespan of Drosophila Melanogaster - PubMed
Lutein is one of the major carotenoids in most fruits and vegetables. The effect of lutein on the lifespan of Drosophila melanogaster was investigated. Results

クルクミン SOD-2

Curcumin Ameliorates Arterial Dysfunction and Oxidative Stress with Aging
We tested the hypothesis that curcumin supplementation would reverse arterial dysfunction and vascular oxidative stress with aging. Young (Y, 4–6 mo) and old (O
Curcumin-supplemented Diets Increase Superoxide Dismutase Activity and Mean Lifespan in Drosophila - PubMed
Curcumin is a polyphenolic bioactive compound in turmeric. We examined if antioxidant effects of curcumin are associated with lifespan extension in Drosophila.

はちみつ SOD

The Effects of Honey Supplementation on Seminal Plasma Cytokines, Oxidative Stress Biomarkers, and Antioxidants During 8 Weeks of Intensive Cycling Training - PubMed
The purpose of this study was to examine the effects of natural honey supplementation on seminal plasma cytokines, oxidative stress biomarkers, and antioxidants

タンポポ(タラクサムオフィシナール) SOD

Taraxacum Officinale Protects Against Lipopolysaccharide-Induced Acute Lung Injury in Mice - PubMed
These results suggest that Taraxacum officinale protects against LPS-induced ALI in mice.

エラグ酸 SOD

Antioxidant and Apoptosis-Inducing Activities of Ellagic Acid - PubMed
Ellagic acid exhibited both antioxidant activity in V79-4 cells and apoptosis-inducing activity in HOS cells through the up-regulation of Bax and activation of

N-アセチル-システイン Sirt1経路

N-acetyl-l-cysteine Ameliorates the PM 2.5-induced Oxidative Stress by Regulating SIRT-1 in Rats - PubMed
Silent information regulator 1 (SIRT1), a class III histone deacetylase, plays a major role in combating cellular oxidative stress injury. However, the role of

SODの材料 銅、亜鉛、マンガン

ホルモン

エストロゲン

濃度、時間に依存して変動。

Molecular Vision: Mitochondrial superoxide dismutase activation with 17 β-estradiol-treated human lens epithelial cells

プロゲステロン

Estrogen plus progestin increase superoxide dismutase and total antioxidant capacity in postmenopausal women
(2015). Estrogen plus progestin increase superoxide dismutase and total antioxidant capacity in postmenopausal women. Climacteric: Vol. 18, No. 3, pp. 379-388.
筋力トレーニング

21週間の筋力トレーニングは健康な中年男性の抗酸化酵素を増加させたが、持久トレーニンググループでは有意な影響を与えなかった。

Effects of Strength and Endurance Training on Antioxidant Enzyme Gene Expression and Activity in Middle-Aged Men - PubMed
This study was aimed at investigating the effects of a 21-week period of progressive strength or endurance training on peripheral blood mononuclear cells (PBMC)
Exercise and Hormesis: Activation of Cellular Antioxidant Signaling Pathway - PubMed
Contraction-induced production of reactive oxygen species (ROS) has been shown to cause oxidative stress to skeletal muscle. As an adaptive response, muscle ant

SOD-2活性の低下

セレン

Selenium Attenuates Expression of MnSOD and Uncoupling Protein 2 in J774.2 Macrophages: Molecular Mechanism for Its Cell-Death and Antiinflammatory Activity - PubMed
Selenium can activate cell death. However, the mechanism of action is not yet fully defined. We hypothesized that selenium may impede mitochondrial superoxide d
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